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Transgeneron Therapeutics, Inc.
Transgeneron PDF Print E-mail
Transgeneron Therapeutics, Inc., was founded in April 2007 to apply a novel pharmacological approach to regenerative medicine;  the company develops therapeutics that promote tissue regeneration by reprogramming healthy tissue.  This therapeutic reprogramming causes cells to “trans-differentiate” into cells that can replace diseased or degenerated organs.

 "Beyond Stem Cell Biology - the Next Generation of Regenerative Medicine"

Transgeneron is focusing on the next scientific threshold of regenerative medicine – combining the understanding of embryonic cell development with a traditional therapeutic approach.  The Company's therapeutics could reprogram existing, healthy cells to replace damaged or diseased functional tissue without surgical intervention, without external stem cells and without bone marrow transplants.

In the laboratory of our Scientific Founder, Dr. Lijun Yang, Associate Professor, University of Florida, Department of Pathology, Immunology and Laboratory Medicine, as well as in our own experiments, treatments with the developmentally controlled transcription factors have successfully regenerated insulin producing cells in diabetic animals.

Dr. Yang’s laboratory has demonstrated that the injection of a recombinant transcription factor, Pdx-1, results in reversal of hyperglycemia in diabetic mice promoting pancreatic beta-cell regeneration and reprogramming of both liver and pancreas cells into functional endocrine insulin-producing cells.  This reversal of hyperglycemia could be applicable to both Type I and Type II diabetes in humans.

Based in Gainesville, Florida, Transgeneron has developed a strong scientific and management team, and has licensed patents from several institutions to form the basis of the Company’s first clinical candidate, Tgth-0100. The company is privately held and has received funding from Takeda Research Investment, Palo Alto, California.
 

"Beyond Stem Cell Biology - the Next Generation of Regenerative Medicine"